KLIMISCH ET AL.1997 AND PDF

Data quality is very important for chemical risk assessment and regulatory decision-making. Klimisch et al developed a scoring system to assess the reliability of data from toxicological and ecotoxicological studies. This rating system has been extended to physico-chemical studies and is now accepted by many regulatory authorities and organizations. In this article, we will show you how to use the Klimisch scoring system to evaluate data reliability. Data is assigned to one of the 4 scores below. Generally speaking, only Klimisch scores of 1 or 2 can be used to cover an endpoint as reliable data.

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Data quality is very important for chemical risk assessment and regulatory decision-making. Klimisch et al developed a scoring system to assess the reliability of data from toxicological and ecotoxicological studies. This rating system has been extended to physico-chemical studies and is now accepted by many regulatory authorities and organizations. In this article, we will show you how to use the Klimisch scoring system to evaluate data reliability.

Data is assigned to one of the 4 scores below. Generally speaking, only Klimisch scores of 1 or 2 can be used to cover an endpoint as reliable data. Klimisch score 3 and 4 data are only used as supporting studies or as part of a weight of evidence approach.

It can also be found in the table below. Expert judgement is needed. Although well established and widely used, the Klimisch categories lack, however, detailed criteria for assigning data quality. It is an excel-based tool developed by ECVAM to provide comprehensive criteria and guidance for evaluations of the inherent quality of toxicological data.

ToxRTool consists of two parts, one to evaluate in vivo and one to evaluate in vitro data. It is applicable to various types of experimental data, endpoints and studies study reports, peer-reviewed publications and leads to the assignment to Klimisch categories 1, 2 or 3.

One only needs to answer some questions about existing data and will get assigned Klimisch scores. We do not provide consultancy services. If you have questions or need any help, please contact our sponsor. You may also find an expert in CSP business directory below.

If you are a consultant, you may get yourself listed in CSP business directory free or sponsor this page to leave your contact info on this page.. Klimisch Scoring System Data is assigned to one of the 4 scores below. To download the tool, please click the link below. What Is New? Hot Articles.

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Klimisch score

The Klimisch score is a method of assessing the reliability of toxicological studies, mainly for regulatory purposes, that was proposed by H. Klimisch, M. Andreae and U. Often studies are performed to more than one test guideline where they are in agreement as to the requirements. The scoring system is the standard method used in both the EU regulatory schemes e. Generally, only Klimisch scores of 1 or 2 can be used by themselves to cover an endpoint.

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