Very high serum levels of vitamin B 12 , following dietary megadosing, does not seem to have any observable deleterious effects 2. Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. Updating… Please wait. Unable to process the form. Check for errors and try again. Thank you for updating your details.

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Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Not surprisingly, a rise of the cobalamin concentration in serum is one of the diagnostic criteria for the latter two diseases. The increase in circulating cobalamin levels is predominantly caused by enhanced production of haptocorrin.

Several liver diseases like acute hepatitis, cirrhosis, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin. Altogether it can be concluded that an observed elevation of cobalamin in blood merits the a full diagnostic work up to assess the presence of disease. This site needs JavaScript to work properly.

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Full-text links Cite Favorites. Abstract Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Similar articles [The significance of an elevated cobalamin concentration in the blood]. Ermens AA, et al. Ned Tijdschr Geneeskd. PMID: Dutch. The pathophysiology of elevated vitamin B12 in clinical practice. Epub Feb PMID: Review. Chiche L, et al. Rev Med Interne. Epub Sep PMID: French. Vitamin B12 in health and disease: part I--inherited disorders of function, absorption, and transport.

Kapadia CR. Our experience and a review]. Zulfiqar AA, et al. Medicina B Aires. Show more similar articles See all similar articles. Urbanski G, et al. J Clin Med. Flores-Guerrero JL, et al. Micronutrient Deficiencies in Medical and Surgical Inpatients.

Berger MM, et al. Capelli I, et al. Higher maternal plasma folate, vitamin B 12 and homocysteine levels in women with preeclampsia. Pisal H, et al.

J Hum Hypertens. Epub Jan PMID: Show more "Cited by" articles See all "Cited by" articles. Publication types Review Actions. MeSH terms Animals Actions. Humans Actions. Substances Vitamin B 12 Actions. Full-text links [x] Elsevier Science. Copy Download.


Significance of Elevated Cobalamin (Vitamin B12) Levels in Blood

Hypervitaminosis is a condition of abnormally high storage levels of vitamins , which can lead to toxic symptoms. Specific medical names of the different conditions are derived from the vitamin involved: an excess of vitamin A , for example, is called hypervitaminosis A. Hypervitaminoses are primarily caused by fat-soluble vitamins D and A , as these are stored by the body for longer than the water-soluble vitamins. Generally, toxic levels of vitamins stem from high supplement intake and not from natural food. Toxicities of fat-soluble vitamins can also be caused by a large intake of highly fortified foods, but natural food rarely deliver dangerous levels of fat-soluble vitamins. Vitamin overdose can be avoided by not taking more than the normal or recommended amount of multi-vitamin supplement shown on the bottle.






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