EL METABOLISMO DE LOS TUMORES OTTO HEINRICH WARBURG PDF

PubMed Central. Foraminotomia cervical posterior en el tratamiento de conflictos foraminales. En este trabajo evaluamos nuestra serie de pacientes tratados por esta via. La VAS preoperatoria en promedio fue de 8. La media en la Neck Disability Index al inicio fue de

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PubMed Central. Foraminotomia cervical posterior en el tratamiento de conflictos foraminales. En este trabajo evaluamos nuestra serie de pacientes tratados por esta via. La VAS preoperatoria en promedio fue de 8. La media en la Neck Disability Index al inicio fue de Potencial eficacia del metotrexato. The storage plan provides criteria for portable exhauster storage, periodic inspections during storage, and retrieval from storage.

Published by Elsevier Inc. Seguridad del paciente en Radioterapia Intraoperatoria: Impacto de los elementos controlados por el Radiofisico. Introduccion: En la administracion de la radioterapia intervienen profesionales y equipos de tratamiento , por lo que existe el riesgo de error y se precisa que dicho equipamiento funcione conforme a lo esperado.

A los radiofisicos les corresponde participar en las actividades de garantia o aseguramiento de la calidad, incluyendo el control de calidad de los equipos, y en la evaluacion de los riesgos asociados. La radioterapia intraoperatoria RIO es una tecnica radioterapica de intensificacion de dosis, altamente selectiva, dirigida a volumenes anatomicos restringidos durante el tratamiento quirurgico oncologico, basada en la administracion de una dosis absorbida alta por medio de un haz de electrones tras el examen visual directo del lecho tumoral.

Como incorporar los ultimos avances en el refuerzo de la seguridad en radioterapia es una tarea ambiciosa y compleja, resulta mas concreta y de inmediata aplicacion su introduccion en la RIO.

El objetivo es analizar los elementos que reducen los riesgos y aumentan la seguridad en la RIO y su dosimetria, y valorar la funcion del radiofisico en esta labor. Se realizo un analisis de modos de fallo y efectos failure mode and effect analysis, FMEA con el fin de identificar los elementos que forman la RIO y aplicar las herramientas necesarias para la minimizacion de los riesgos y la mejora de la seguridad en la tecnica. Se estudiaron las verificaciones diarias de dicho acelerador Precise con el control estadistico de procesos statistical process control, SPC y se simularon intervenciones para devolverlo al estado llamado en control.

El SPC. These requirements are presented in three parts: preparation for storage, storage maintenance and testing, and retrieval from storage. The exhauster component identification numbers listed in this document contain the prefix POR or POR depending on which exhauster is being used.

Cinco de ellos fueron reoperados. Porphyromonas gingivalis, a keystone pathogen for periodontitis, utilizes the T9SS to transport many proteins including the gingipain virulence factors across the outer membrane and attach them to the cell surface via a sortase-like mechanism. At least 11 proteins have been identified as components of the T9SS including Por K, Por L, Por M, Por N and Por P, however the precise roles of most of these proteins have not been elucidated and the structural organization of these components is unknown.

Por L and Por M were found to form a separate stable complex. Por K and Por N were protected from proteinase K cleavage when present in undisrupted cells, but were rapidly degraded when the cells were lysed, which together with bioinformatic analyses suggests that these proteins are exposed in the periplasm and anchored to the outer membrane via the Por K lipid.

Chemical cross-linking and mass spectrometry analyses confirmed the interaction between Por K and Por N and further revealed that they interact with the PG outer membrane protein. This is the first report showing the structural organization of any T9SS component.

Gorasia, Dhana G. Karger AG, Basel. The Type IX secretion system T9SS is a versatile multi-protein complex restricted to bacteria of the Bacteriodetes phylum and responsible for the secretion or cell surface exposition of diverse proteins that participate to S-layer formation, gliding motility or pathogenesis.

The T9SS is poorly characterized but a number of proteins involved in the assembly of the secretion apparatus in the oral pathogen Porphyromonas gingivalis have been identified based on genome substractive analyses. Deletion of por X in P. Here, we show that Por X and the soluble cytoplasmic domain of Por Y interact.

Using electrophoretic mobility shift, DNA-protein co-purification and heterologous host expression assays, we demonstrate that Por X does not bind T9SS gene promoters and does not directly regulate expression of the T9SS genes. This redundancy is required since both of the tank ventilation systems have been declared as Safety Class systems. Identification of Porphyromonas gingivalis proteins secreted by the Por secretion system. The Gram-negative bacterium Porphyromonas gingivalis possesses a number of potential virulence factors for periodontopathogenicity.

In particular, cysteine proteinases named gingipains are of interest given their abilities to degrade host proteins and process other virulence factors such as fimbriae.

To identify proteins other than gingipains secreted by the Por SS, we compared the proteomes of P. Sixteen spots representing 10 different proteins were present in the particle-free culture supernatant of the Por SS-proficient strain but were absent or faint in that of the Por SS-deficient strain. These results indicate that the Por SS is used for secretion of a number of proteins other than gingipains and that the CTDs of the proteins are associated with the Por SS-dependent secretion.

Published by Blackwell Publishing Ltd. All rights reserved. Management strategies for organic livestock effluents,innovative treatment and valorization. It includes measurements of bearing vibration levels, pressure decay testing, programmable logic controller interlocks, high vacuum, flow and pressure control functional testing. The purpose of Acceptance testing documented by this report was to demonstrate compliance of the exhausters with the performance criteria established within HNF, Rev.

Additional testing not required by the ATP was also performed to assist in the disposition and close out of receiving inspection report and for application design information system curve. Results of this testing are also captured within this document. Prognostic factors in multiple myeloma: definition of risk groups in previously untreated patients: a Grupo Argentino de Tratamiento de la Leucemia Aguda study.

Four hundred ten previously untreated multiple myeloma patients entered onto two consecutive Grupo Argentino de Tratamiento de la Leucemia Aguda GATLA protocols were analyzed to identify significant prognostic factors influencing survival. The univariate analysis selected the following variables: performance status, renal function, percentage of bone marrow plasma cells at diagnosis, hemoglobin, and age.

A multivariate analysis showed that performance status, renal function, percentage of bone marrow plasma cells, hemoglobin, and age were the best predictive variables for survival.

In our patient population, this model proved to be superior to the Durie-Salmon staging system in defining prognostic risk groups, and separating patients with significantly different risks within each Durie-Salmon stage. Cytochrome P reductase POR is a microsomal electron transport protein essential to cytochrome Pmediated drug metabolism and sterol and bile acid synthesis.

The conditional deletion of hepatic POR gene expression in mice results in a marked decrease in plasma cholesterol levels counterbalanced by the accumulation of triglycerides in lipid droplets in hepatocytes. To evaluate the role of cholesterol and bile acid synthesis in this hepatic lipidosis, as well as the possible role of lipid transport from peripheral tissues, we developed a stable, small interfering RNA siRNA -mediated cell culture model for the suppression of POR.

Immunofluorescent analysis revealed a marked accumulation of lipid droplets in cells by day 15, accompanied by a nearly 2-fold increase in cellular triglyceride content, replicating the lipidosis seen in hepatic POR -null mouse liver. In contrast, suppression of CYP51A1 lanosterol demethylase did not result in lipid accumulation, indicating that loss of cholesterol synthesis is not the basis for this lipidosis.

Indeed, addition of cholesterol to the medium appeared to augment the lipidosis in POR -suppressed cells, whereas removal of lipids from the medium reversed the lipidosis. Oxysterols did not accumulate in POR -suppressed cells, discounting a role for liver X receptor in stimulating triglyceride synthesis, but addition of chenodeoxycholate significantly repressed lipid accumulation, suggesting that the absence of bile acids and loss of farnesoid X receptor stimulation lead to excessive triglyceride synthesis.

Suppression of cytochrome P reductase POR expression in hepatoma cells replicates the hepatic lipidosis observed in hepatic POR -null mice. Prior to taking ownership, acceptance testing was performed at the vendors. However at the conclusion of testing a number of issues remained that required resolution before the exhausters could be used by Project W The purpose of acceptance testing documented by this report was to demonstrate compliance of the exhausters with the performance criteria established within HNF-O49O, Rev.

Outer membrane vesicles from Neisseria gonorrhoeae target Por B to mitochondria and induce apoptosis. Neisseria gonorrhoeae causes the sexually transmitted disease gonorrhoea by evading innate immunity. Colonizing the mucosa of the reproductive tract depends on the bacterial outer membrane porin, Por B, which is essential for ion and nutrient uptake. Por B is also targeted to host mitochondria and regulates apoptosis pathways to promote infections.

How Por B traffics from the outer membrane of N. Here, we show that N. The porin was targeted to mitochondria of macrophages after exposure to purified OMVs and wild type N. This was associated with loss of mitochondrial membrane potential, release of cytochrome c, activation of apoptotic caspases and cell death in a time-dependent manner.

This shows that N. The phylum Bacteroidetes is large and diverse, with rapid gliding motility and the ability to digest macromolecules associated with many genera and species. Recently, a novel protein secretion system, the Por secretion system Por SS , was identified in two members of the phylum, the gliding bacterium Flavobacterium johnsoniae and the nonmotile oral pathogen Porphyromonas gingivalis.

The components of the Por SS are not similar in sequence to those of other well-studied bacterial secretion systems. The F. Comparative analysis of 37 genomes of members of the phylum Bacteroidetes revealed the widespread occurrence of gliding motility genes and Por SS genes.

Genes associated with other bacterial protein secretion systems were less common. The results suggest that gliding motility is more common than previously reported. Mutants of ARF6 defective in GTP binding and hydrolysis have a marked effect on endocytic trafficking and the gross morphology of the peripheral membrane system. These findings indicate that ARF6 and Rac1 function on distinct signaling pathways to mediate cytoskeletal reorganization, and suggest a role for POR 1 as an important regulatory element in orchestrating cytoskeletal rearrangements at the cell periphery induced by ARF6 and Rac1.

The most common noncanonical uses were…. This involves creating tickets for specific work items and track the progress to complete these specific work items. Low oxygen environment facilitates embryo availability for older ovarian responders PORs. No significant differences were observed in normal fertilization rates The number of available embryos 1.

It showed no significant differences in the implantation rates The employ of low oxygen culture did not improve clinical pregnancy rate for older PORs.

However, it benefited early embryonic development for older PORs. Antigenic topology of chlamydial Por B protein and identification of targets for immune neutralization of infectivity.

The outer membrane protein Por B is a conserved chlamydial protein that functions as a porin and is capable of eliciting neutralizing Abs. A topological antigenic map was developed using overlapping synthetic peptides representing the Chlamydia trachomatis Por B sequence and polyclonal immune sera. To identify which antigenic determinants were surface accessible, monospecific antisera were raised to the Por B peptides and were used in dot-blot and ELISA-based absorption studies with viable chlamydial elementary bodies EBs.

The ability of the surface-accessible antigenic determinants to direct neutralizing Ab responses was investigated using standardized in vitro neutralization assays. Collectively, the EB absorption and dot-blot assays established that the immunoreactive Por B Ags were exposed on the surface of chlamydial EBs.

Peptide-specific antisera raised to the surface-accessible Ags neutralized chlamydial infectivity and demonstrated cross-reactivity to synthetic peptides representing analogous C. Furthermore, neutralization of chlamydial infectivity by C. These findings demonstrate that Por B Ags may be useful for development of chlamydial vaccines. The outer membrane protein Por B of Neisseria meningitidis is a pore-forming protein which has various effects on eukaryotic cells.

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The FDA, often criticized for allowing toxic substances to be sold as food, is taking a major step toward preventing disease. This means that manufacturers will no longer be allowed to sell them without first producing scientific proof that they are safe. And frankly, no one could prove such a thing, without resorting to fuzzy math, trickery, deceit and outright corruption. Using hydrogenated oil instead of healthy oil helps the bottom line of the manufacturer by increasing the shelf life and lowering the cost of its products, but they are terrible for your body. The World Health Organization reports that heart disease is the leading cause of death worldwide. According to Dr. Prior to , the FDA did not require manufacturers to disclose the inclusion of trans fats on labels of their packaged goods.

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